Tysabri withdrawal calls entire class into question

Corrigendum: Chemical formation of hybrid di-nitrogen calls fungal codenitrification into question

This corrects the article DOI: 10.1038/srep39077.

Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumor suppressor functio

Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function

The Runx3 transcription factor regulates cell fate decisions during embryonic development and in adults. It was previously reported that Runx3 is strongly expressed in embryonic and adult gastrointestinal tract (GIT) epithelium (Ep) and that its loss causes gastric cancer. More than 280 publications have based their research on these findings and concluded that Runx3 is indeed a tumour suppress...

Oxford TB vaccine study calls into question selective use of animal data

In July 2009, researchers began a clinical trial in infants in South Africa, testing the newest hope for an improved vaccine against tuberculosis. Nearly 2800 infants took part. Their parents consented on the basis of information that included the statement that the trial vaccine, MVA85A, “has been tested in animals and was shown to be safe and effective.” Similar statements had been used to ob...

Chemical formation of hybrid di-nitrogen calls fungal codenitrification into question

Removal of excess nitrogen (N) can best be achieved through denitrification processes that transform N in water and terrestrial ecosystems to di-nitrogen (N2) gas. The greenhouse gas nitrous oxide (N2O) is considered an intermediate or end-product in denitrification pathways. Both abiotic and biotic denitrification processes use a single N source to form N2O. However, N2 can be formed from two ...